Microarrays for an Integrative Genomics (Computational Molecular Biology) (Computational Molecular Biology Series)

Functional genomics--the deconstruction of the genome to determine the biologicalfunction of genes and gene interactions--is one of the most fruitful new areas of biology. Thegrowing use of DNA microarrays allows researchers to assess the expression of tens of thousands ofgenes at a time. This quantitative change has led to qualitative progress in our ability tounderstand regulatory processes at the cellular level.This book provides a systematic introductionto the use of DNA microarrays as an investigative tool for functional genomics. The presentation isappropriate for readers from biology or bioinformatics. After presenting a framework for the designof microarray-driven functional genomics experiments, the book discusses the foundations foranalyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature anddata models, clinical applications of functional genomics research, and the future of functionalgenomics.